Association of Frailty with Serum Vitamin D and Parathyroid Hormone Levels

Şemsinnur Göçer; Özlem Balbaloğlu

doi:10.31067/acusaglik.948574

Research Article

BibTex

RIS

Cite

Association of Frailty with Serum Vitamin D and Parathyroid Hormone Levels

Year 2022, , 119 - 125, 01.01.2022

Şemsinnur Göçer , Özlem Balbaloğlu

https://doi.org/10.31067/acusaglik.948574

Abstract

Objective: Given that there is limited number of studies investigated joint effect of vitamin D and parathyroid hormone (PTH) in frailty syndrome, we aimed to evaluate association of frailty with serum vitamin D and PTH levels.
Materials and Methods: This is a cross-sectional study conducted on individuals aged >65 years. In this cross-sectional study, data were collected using sociodemographic data sheet, Fatigue, Resistance, Ambulation, Illnesses, & Loss of Weight (FRAIL) scale and Study of Osteoporotic Fracture (SOF) index via face-to-face interview. The study included data from 513 subjects. Chi-square test was used in analyses. A p value<0.05 was considered as statistically significant.
Results: The mean age was 71.9±6.4 years in the study population. Of the subjects, 75.2% were women and 77.2% were married while 61.8% were illiterate and 99.2% had own income. The prevalence of frailty elder was found as 46.8% by FRAIL scale and 51.3% by SOF index while pre-fail elder prevalence was found as 45.2% by FRAIL scale and 33.3% by SOF index.
Conclusion: It was found that frail elder prevalence was increased by advancing age, female gender and presence of comorbidity and that low serum vitamin D and elevated PTH levels were closely associated with prevalence of frail elder.

Keywords

Fraility, Vitamin D, Parathyroid, Elderly

Supporting Institution

Destekleyen kurum bulunmamaktadır.

Project Number

Thanks

References

1. Rockwood K, Song X, MacKnight C et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005; 173: 489–95. doi: 10.1503/cmaj.050051.
2. Topinkova E. Aging, disability and frailty. Ann Nutr Metab 2008; 52(Suppl 1): 6–11. https://doi.org/10.1159/000115340
3. Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults. toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/ National Institute on Ageing Research Conference on Frailty in Older Adults. J Am Geriat Soc 2006; 54(6):991-1001. doi: 10.1111/j.1532-5415.2006.00745.x.
4. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004;59(3):255-63. doi: 10.1093/gerona/59.3.m255.
5. Rose M, Pan H, Levinson MR, Staples M. Can frailty predict complicated care needs and length of stay? Intern Med J 2014; 44(8),800-5. doi: 10.1111/imj.12502.
6. Byard RW. Frailty syndrome–medicolegal considerations. Journal of forensic and legal medicine. 2015;30:34-8. Doı: 10.1016/j.jflm.2014.12.016
7. Zaslavsky O, Cochrane BB, Thompson HJ, Woods NF, Herting JR, LaCroix AA. Frailty: A Review Of The First Decade Of Research. Biological Research For Nursing 2012; 15(4):422-432. doi: 10.1177/1099800412462866.
8. Shardell M, Hicks GE, Miller RR et al. Association of low vitamin D levels with the frailty syndrome in men and women. J Gerontol A Biol Sci Med Sci 2009; 64: 69–75. doi: 10.1093/gerona/gln007.
9. Wilhelm-Leen ER, Hall YN, Deboer IH, Chertow GM. Vitamin D deficiency and frailty in older Americans. J Intern Med 2010; 268: 171–80. doi: 10.1111/j.1365-2796.2010.02248.x.
10. Ensrud KE, Ewing SK, Fredman L et al. Circulating 25-hydroxyvitamin D levels and frailty status in older women. J Clin Endocrinol Metab 2010; 95: 5266–73. Doı: 10.1210/jc.2010-2317
11. Chang CI, Chan DC, Kuo KN, Hsiung CA, Chen CY. Vitamin D insufficiency and frailty syndrome in older adults living in a Northern Taiwan community. Arch Gerontol Geriatr 2010; 50(Suppl 1): S17–21. doi: 10.1016/S0167-4943(10)70006-6.
12. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001; 22:477–501. doi: 10.1210/edrv.22.4.0437.
13. Visser M, Deeg DJ, Lips P. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 2003; 88: 5766–72. doi: 10.1210/jc.2003-030604.
14. Houston DK, Cesari M, Ferrucci L et al. Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2007; 62: 440–6. doi: 10.1093/gerona/62.4.440.
15. Fried L P, Tangen C M, Walston J.et al Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 56(3):M146-56.doi: 10.1093/gerona/56.3.m146.
16. Mitnitski A, Song X, Skoog I.et al Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality. J Am Geriatr Soc 53(12):2184-9. doi: 10.1111/j.1532-5415.2005.00506.x.
17. Akın S, Mazıcıoglu MM, Mucuk S, Gocer S, Deniz Şafak E, Arguvanlı S, et al. The prevalence of frailty and related factors in community-dwelling Turkish elderly according to modified Fried Frailty Index and FRAIL scales. Aging Clin Exp Res 2015; 27(5): 703–9. Doi: 10.1007/s40520-015-0337-0.
18. Eyigor S, Kutsal YG, Duran E, Huner B, Paker N, Durmus B, et al. Frailty prevalence and related factors in the older adult—FrailTURK Project. Age (Omaha) 2015; 37(3): 50.
19. Morley JE, Malmstrom TK, Miller DK (2012) A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging 16(7):601–608. doi: 10.1007/s12603-012-0084-2.
20. Ensrud KE, Ewing SK, Taylor BC, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 2008; 168(4):382-9. doi: 10.1001/archinternmed.2007.113.
21. Jung HW, Yoo HJ, Park SY, Kim SW, Choi JY, Yoon SJ, et al. The Korean version of the FRAIL scale: clinical feasibility and validity of assessing the frailty status of Korean elderly. Korean J Intern Med. 2016;31(3):594-600. doi: 10.3904/kjim.2014.331.
22. Diaz de Leon Gonzalez E, Gutierrez Hermosillo H, Martinez Beltran JA, Chavez JH, Palacios Corona R, Salinas Garza DP, et al. Validation of the FRAIL scale in Mexican elderly: results from the Mexican Health and Aging Study. Aging Clin Exp Res. 2016;28(5):901-8. doi: 10.1007/s40520-015-0497-y.
23. Dong L, Qiao X, Tian X, Liu N, Jin Y, Si H, et al. Cross-Cultural Adaptation and Validation of the FRAIL Scale in Chinese Community-Dwelling Older Adults. J Am Med Dir Assoc. 2017. 60 doi: 10.1016/j.jamda.2017.06.011.
24. Gardiner PA, Mishra GD, Dobson AJ. Validity and responsiveness of the FRAIL scale in a longitudinal cohort study of older Australian women. J Am Med Dir Assoc. 2015;16(9):781-3. doi: 10.1016/j.jamda.2015.05.005.
25. Lopez D, Flicker L, Dobson A. Validation of the frail scale in a cohort of older Australian women. J Am Geriatr Soc. 2012;60(1):171-3. doi: 10.1111/j.1532-5415.2011.03746.x.
26. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M et al (1982–1983) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17:37–49. doi: 10.1016/0022-3956(82)90033-4.
27. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385
28. Lally F, Crome P. Understanding frailty. Postgrad Med J 2007; ;83(975);16–20. doi: 10.1136/pgmj.2006.048587
29. Bahat G, Saka B, Tufan F, Akın S, Çakır FN, Yüce N, Erten N, Karan MA. Bakımevinde Kalan Yatağa Bağımlı Olmayan Yaşlılarda Kırılganlık. Geriatri ve Geriatrik Nöropsikiyatri Dergisi 2009; 1(Özel):91-92.
30. Strandberg T. E, Pitkala K. H, Tilvis R.S. Frailty in older people. European Geriatric Medicine, 2011; 2(6): 344–355. https://doi.org/10.1016/j.eurger.2011.08.003
31. Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL, et al. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc. 2005;53(8):1321- 30. doi: 10.1111/j.1532-5415.2005.53405.x.
32. Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves,P, Zeger SL, Fried LP Phenotype of frailty: characterization in the women's health and aging studies. Journal of Gerontology: Medical Sciences 2006;61( 3); 262-266. doi: 10.1093/gerona/61.3.262.
33. Pegoran MS, Tavares DMS. Factors associated with the frailty syndrome in elderly individuals living in the urban area. Rev Lat Am Enfermagem 2014; 22(5):874-882. doi: 10.1590/0104-1169.0213.2493.
34. Zhou J, Huang P, Liu P, Hao Q, Chen S, Dong B, et al. Association of vitamin D deficiency and frailty: A systematic review and meta-analysis. Maturitas 2016; 94: 70–6. doi: 10.1016/j.maturitas.2016.09.003.
35. Artaza-Artabe I, Sáez-López P, Sánchez-Hernández N, Fernández-Gutierrez N, Malafarina V. The relationship between nutrition and frailty: Effects of protein intake, nutritional supplementation, vitamin D and exercise on muscle metabolism in the elderly. A systematic review. Maturitas 2016; 93: 89–99. doi: 10.1016/j.maturitas.2016.04.009.
36. Eyigor S., Kutsal Y. G. (2010). Kırılgan Yaslıya Yaklasım, Türk Fiz Tıp Rehab Dergisi, 56:135-40.
37. Chowdhury R, Peel NM, Krosch M, Hubbard RE. Frailty and chronic kidney disease: A systematic review. Arch Gerontol Geriatr 2017;68:135-42. doi: 10.1016/j.archger.2016.10.007.
38. Tajar A, Lee DM, Pye SR, O’Connell MD, Ravindrarajah R, Gielen E, et al. The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men. Age Ageing 2013;42(3):352-9. doi: 10.1093/ageing/afs162.
39. Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006; 92: 4–8. Doi: 10.1016/j.pbiomolbio.2006.02.016
40. Cesari M, Penninx BW, Pahor M et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2004; 59: 242–8. doi: 10.1093/gerona/59.3.m242.
41. Deutch SR, Jensen MB, Christiansen PM, Hessov I. Muscular performance and fatigue in primary hyperparathyroidism. World J Surg 2000; 24: 102–7. doi: 10.1007/s002689910019.