Öz
Familial Mediterranean fever FMF is a hereditary disease characterised by recurrent attacks of fever with peritonitis, pleuritis, arthritis or erysipelas-like rash. As its name suggests, FMF is seen primarily among individuals of Mediterranean ancestry, particularly Turks, Armenians, non-Ashkenazi Jews and Arabs. Familial Mediterranean fever is inherited as an autosomal recessive disorder. 32 year old female patient was admitted with severe abdominal pain occurring periodically with the onset of first menstruation after pregnancy. Abdominal pain was not accompanied by additional symptoms such as fever, rash or arthritis. The patient who is investigated due to positive family history was diagnosed with FMF. Episodes were controlled by cyclic colchicine treatment which was given at the perimenstrual period
Anahtar Kelimeler
Kaynakça
- Ben-Chetrit E, Ben-Chetrit A. Familial Mediterranean fever and menstruation. BJOG 2001;108:403-7.
- Berkun Y, Eisenstein EM. Diagnostic criteria of familial Mediterranean fever. Autoimmun Rev. 2014;13:388-90.
- The International FMF Consortium. Ancient missence mutations in a new member of the RORet gene family are likely to cause familial Mediterranean fever. Cell 1997;90:797-807.
- Kim KT, Jang HJ, Lee JE, Kim MK, Yoo JJ, Lee GY, Kae SH, Lee J.n Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy. Intest Res. 2015;13:287-90.
- Ben-Chetrit E, Levy M. Familial Mediterranean fever. Lancet 1998;351:659-64.
- Schwartz J. Periodic peritonitis, onset simultaneously with menstruation. Ann Intern Med1960;53:407-11.
- Milano AM. Familial Mediterranean fever associated with menstruation. Am J Gastroenterol1981;76:363-4.
- Koka S, Petro TM, Reinhardt RA. Estrogen inhibits interleukin-1 beta induced interleukin 6 production by human osteoblast-like cells. J Interferon Cytokine Res 1998;18:479-83.
- Otto G, Braconier J, Andreassen A, Svanborg C. Interleukin-6 and disease severity in patients with bacteremic and nonbacteremic febrile urinary tract infection. J Infect Dis 1999;179:172-9.
- Koh KK, Bui MN, Mincemoyer R, CannonRO. Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women. Am J Cardiol 1997;80:1505-7.
- Cronstein BN, Molad Y, Reibman J, Balakane E, Levin RJ, Weissmannm G. Colchicine alters the quantitative and the qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest1995;96:994-1002.
- Tunca M, Tankurt E, Akbaylar Akpinar H, Akar S, Hizli N, Gonen O. The eficacy of interferon alpha on colchicine resistant familial Mediterranean fever attacks: a pilot study. Br J Rheumatol 1997;36:1005-1008.
- Obici L, Merlini G. Amyloidosis in autoinflammatory syndromes. Autoimmun Rev 2012;12:14–7.
- Papadopoulos VP, Giaglis S, Mitroulis I, Ritis K. The population genetics of familial mediterranean fever: a meta-analysis study. Ann Hum Genet. 2008;72:752-61
Öz
Ailevi Akdeniz Ateşi FMF , periyodik olarak ortaya çıkan ateş, karın ağrısı, poliserözit ve erezipel benzeri döküntülerle karakterize herediter geçişli bir hastalıktır. Akdeniz ve yakın Ortadoğu bölgesinden adını alan hastalık Türk, Ermeni, Yahudi ve Araplar gibi bazı etnik gruplara spesifiktir. FMF genetik geçişli otozomal resesif bir hastalıktır. 32 yaşında bayan hasta ilk doğum sonrası menstrüasyon başlamasıyla periyodik olarak ortaya çıkan şiddetli karın ağrısı şikayeti ile başvurdu. Karın ağrısına ateş yüksekliği, döküntü ya da artrit gibi ek semptomlar eşlik etmiyordu. Pozitif aile öyküsü bulunması nedeni ile tetkik edilen hastaya FMF tanısı kondu. Menstrüasyon dönemlerinde siklik olarak kolşisin tedavisi düzenlenerek atakları kontrol altına alındı
Anahtar Kelimeler
Kaynakça
- Ben-Chetrit E, Ben-Chetrit A. Familial Mediterranean fever and menstruation. BJOG 2001;108:403-7.
- Berkun Y, Eisenstein EM. Diagnostic criteria of familial Mediterranean fever. Autoimmun Rev. 2014;13:388-90.
- The International FMF Consortium. Ancient missence mutations in a new member of the RORet gene family are likely to cause familial Mediterranean fever. Cell 1997;90:797-807.
- Kim KT, Jang HJ, Lee JE, Kim MK, Yoo JJ, Lee GY, Kae SH, Lee J.n Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy. Intest Res. 2015;13:287-90.
- Ben-Chetrit E, Levy M. Familial Mediterranean fever. Lancet 1998;351:659-64.
- Schwartz J. Periodic peritonitis, onset simultaneously with menstruation. Ann Intern Med1960;53:407-11.
- Milano AM. Familial Mediterranean fever associated with menstruation. Am J Gastroenterol1981;76:363-4.
- Koka S, Petro TM, Reinhardt RA. Estrogen inhibits interleukin-1 beta induced interleukin 6 production by human osteoblast-like cells. J Interferon Cytokine Res 1998;18:479-83.
- Otto G, Braconier J, Andreassen A, Svanborg C. Interleukin-6 and disease severity in patients with bacteremic and nonbacteremic febrile urinary tract infection. J Infect Dis 1999;179:172-9.
- Koh KK, Bui MN, Mincemoyer R, CannonRO. Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women. Am J Cardiol 1997;80:1505-7.
- Cronstein BN, Molad Y, Reibman J, Balakane E, Levin RJ, Weissmannm G. Colchicine alters the quantitative and the qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest1995;96:994-1002.
- Tunca M, Tankurt E, Akbaylar Akpinar H, Akar S, Hizli N, Gonen O. The eficacy of interferon alpha on colchicine resistant familial Mediterranean fever attacks: a pilot study. Br J Rheumatol 1997;36:1005-1008.
- Obici L, Merlini G. Amyloidosis in autoinflammatory syndromes. Autoimmun Rev 2012;12:14–7.
- Papadopoulos VP, Giaglis S, Mitroulis I, Ritis K. The population genetics of familial mediterranean fever: a meta-analysis study. Ann Hum Genet. 2008;72:752-61
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Case Report |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2017 |
| Yayımlandığı Sayı | Yıl 2017Sayı: 1 |