Öz
Lakrimal kese tümörleri az görülmesine karşın; lokal invazyon, hastalığın tekrarlama ve metastaz yapma potansiyeli yüksektir. Bu tümörlerin nadir görülmesi nedeniyle mevcut tedavi uygulamaları için karar verme çok az sayıdaki olgu raporuna göre yapılmaktadır. Bu tümörlerin büyük kısmı epitelyal kökenlidir. En belirgin semptomları epifora ve orbital medial kantus bölgesinde kitledir. Bu nedenle dakriyosistit ile karışabilir. Tanıda kapsamlı oftalmik muayene ve görüntüleme yöntemleri oldukça önemlidir. Hastalığın primer tedavisi cerrahi olup; adjuvan tedavi olarak radyoterapi ve/veya kemoterapi uygulanabilir. Çalışmamızda simultane integre boost SIB tekniği kullanılarak homojen doz dağılımı ve doz gradientini karşılaştırmak, ayrıca belirli kritik organların dozlarını değerlendirmek amacıyla Hacimsel Yoğunluk Ayarlı Ark Tedavisi VMAT ve Yoğunluk Ayarlı Radyoterapi IMRT planları karşılaştırılmıştır
Anahtar Kelimeler
Kaynakça
- Krishna Y, Coupland SE. Lacrimal Sac Tumors - A Review. Asia Pac Acad J Ophthalmol (Phila) 2017;6:173–8. [CrossRef]
- Skinner HD, Garden AS, Rosenthal DI, Ang K, Morrison WH, Esmaeli B, et al. Outcomes of malignant tumors of lacrimal apparatus: The University of Texas MD Anderson Cancer Center Experience. Cancer 2011;117:2801–10. [CrossRef]
- Schenck NL, Ogura JH, Pratt LL. Cancer of lacrimal sac. Presentation of five cases and review of the literature. Ann Otol Rhinol Laryngol 1973;82:153–61. [CrossRef]
- Parmar DN, Rose GE. Management of lacrimal sac tumours. Eye 2003;17:599–606. [CrossRef]
- Kim HJ, Shields CL, Langer PD. Lacrimal sac tumors: diagnosis and treatment. In: Black EH, Nesi FA, Gladstone G, Levine MR, Calvano CJ, et al., editors. Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, New York; Springer, 2012. pp.609–14.
- Heindle LM, Jünemann AG, Kruese FE, Holbach LM. Tumors of the lacriamal drainage system. Orbit 2010;29:298–306. [CrossRef]
- Montelban A, Lietin B, Louvrier C, Russier M, Kemeny JL, Mom T, Gilain L. Malignant Lacrimal sac tumors. Eur Ann Otorhinolaryngol Head and Neck Dis 2010;127:165–72. [CrossRef]
- Ni C, D’Amico DJ, Fan CQ, Kuo PK. Tumors of the lacrimal sac: a clinicopathological analysis of 82 cases. Int Ophthalmol Clin 1982;22:121–40. [CrossRef]
- Bi YW, Chen RJ, Li XP. Clinical and pathological analysis of primary lacrimal sac tumors. Zhonghua Yan Ke Za Zhi 2007;43:499–504.
- Stefanyszyn MA, Hidayat AA, Pe’er JJ, Flanagan JC. Lacrimal sac tumors. Opthalmic Plast Reconstr Surg 1994;10:169–84.
- Pe’er JJ, Stefanyszyn M, Hidayat AA. Nonepithelial tumors of the lacrimal sac. Am J Ophthalmol 1994;118:650–8.
- Pe’er J. Lacrimal sac tumors. In: Singh AD, Damato BE, Pe’er J, Perry JD, editors. Clinical Ophthalmic Oncology. Berlin: Springer-Verlag; 2014. pp.115–21.
- International Commission on Radiation Units and Measurements. (ICRU) Report 83, Prescribing, recording, and reporting intensity- modulated photon-beam radiation therapy (IMRT). J ICRU 2010;10:41–54.
- Hall EJ. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 2006;65:1–7. [CrossRef]
- Ali MA, Babaiah M, Madhusudhan N, George G. Comparative dosimetric analysis of IMRT and VMAT (RapidArc) in brain, head and neck, breast and prostate malignancies. Int J Cancer Ther Oncol 2015;3:03019. [CrossRef]
- Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys 2008;35:310–7. [CrossRef]
- Wagner D, Christiansen H, Wolff H, Vorwerk H. Radiotherapy of malignant gliomas: comparison of volumetric single arc technique (RapidArc), dynamic intensity- modulated technique and 3D conformal technique. Radiother Oncol 2009;93:593–6. [CrossRef]
- Shaffer R, Nichol AM, Vollans E, Fong M, Nakano S, Moiseenko V, et al. A comparison of volumetric modulated arc therapy and conventional intensity-modulated radiotherapy for frontal and temporal high-grade gliomas. Int J Radiat Oncol Biol Phys 2010;76:1177–84. [CrossRef]
Öz
Although lacrimal sac tumors are rarely seen, they have a high potential for local invasion, local recurrence, and distant metastasis. Given their rarity, decision making for the treatment of these tumors is based on very few case reports. Majority of these tumors are of epithelial origin. Most prominent symptoms are epiphora and mass in the medial canthus region. For this reason, it may be confused with dacryocystitis. Thorough ophthalmic examination and imaging are very important for diagnosis. Primary treatment of the disease is surgery, radiotherapy and/or chemotherapy may be used as adjuvant therapy. In our study, we compared Volumetric Modulated Arc Therapy VMAT and Intensity Modulated Radiation Therapy IMRT plans with the aim of comparing the homogeneous dose distribution and dose gradient using the Simultaneous Integrated Boost SIB technique and also assessing the dose of certain critical organs
Anahtar Kelimeler
Kaynakça
- Krishna Y, Coupland SE. Lacrimal Sac Tumors - A Review. Asia Pac Acad J Ophthalmol (Phila) 2017;6:173–8. [CrossRef]
- Skinner HD, Garden AS, Rosenthal DI, Ang K, Morrison WH, Esmaeli B, et al. Outcomes of malignant tumors of lacrimal apparatus: The University of Texas MD Anderson Cancer Center Experience. Cancer 2011;117:2801–10. [CrossRef]
- Schenck NL, Ogura JH, Pratt LL. Cancer of lacrimal sac. Presentation of five cases and review of the literature. Ann Otol Rhinol Laryngol 1973;82:153–61. [CrossRef]
- Parmar DN, Rose GE. Management of lacrimal sac tumours. Eye 2003;17:599–606. [CrossRef]
- Kim HJ, Shields CL, Langer PD. Lacrimal sac tumors: diagnosis and treatment. In: Black EH, Nesi FA, Gladstone G, Levine MR, Calvano CJ, et al., editors. Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, New York; Springer, 2012. pp.609–14.
- Heindle LM, Jünemann AG, Kruese FE, Holbach LM. Tumors of the lacriamal drainage system. Orbit 2010;29:298–306. [CrossRef]
- Montelban A, Lietin B, Louvrier C, Russier M, Kemeny JL, Mom T, Gilain L. Malignant Lacrimal sac tumors. Eur Ann Otorhinolaryngol Head and Neck Dis 2010;127:165–72. [CrossRef]
- Ni C, D’Amico DJ, Fan CQ, Kuo PK. Tumors of the lacrimal sac: a clinicopathological analysis of 82 cases. Int Ophthalmol Clin 1982;22:121–40. [CrossRef]
- Bi YW, Chen RJ, Li XP. Clinical and pathological analysis of primary lacrimal sac tumors. Zhonghua Yan Ke Za Zhi 2007;43:499–504.
- Stefanyszyn MA, Hidayat AA, Pe’er JJ, Flanagan JC. Lacrimal sac tumors. Opthalmic Plast Reconstr Surg 1994;10:169–84.
- Pe’er JJ, Stefanyszyn M, Hidayat AA. Nonepithelial tumors of the lacrimal sac. Am J Ophthalmol 1994;118:650–8.
- Pe’er J. Lacrimal sac tumors. In: Singh AD, Damato BE, Pe’er J, Perry JD, editors. Clinical Ophthalmic Oncology. Berlin: Springer-Verlag; 2014. pp.115–21.
- International Commission on Radiation Units and Measurements. (ICRU) Report 83, Prescribing, recording, and reporting intensity- modulated photon-beam radiation therapy (IMRT). J ICRU 2010;10:41–54.
- Hall EJ. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 2006;65:1–7. [CrossRef]
- Ali MA, Babaiah M, Madhusudhan N, George G. Comparative dosimetric analysis of IMRT and VMAT (RapidArc) in brain, head and neck, breast and prostate malignancies. Int J Cancer Ther Oncol 2015;3:03019. [CrossRef]
- Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys 2008;35:310–7. [CrossRef]
- Wagner D, Christiansen H, Wolff H, Vorwerk H. Radiotherapy of malignant gliomas: comparison of volumetric single arc technique (RapidArc), dynamic intensity- modulated technique and 3D conformal technique. Radiother Oncol 2009;93:593–6. [CrossRef]
- Shaffer R, Nichol AM, Vollans E, Fong M, Nakano S, Moiseenko V, et al. A comparison of volumetric modulated arc therapy and conventional intensity-modulated radiotherapy for frontal and temporal high-grade gliomas. Int J Radiat Oncol Biol Phys 2010;76:1177–84. [CrossRef]
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Case Report |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Eylül 2019 |
| Yayımlandığı Sayı | Yıl 2019Sayı: 3 |